Treatment | Anti-VEGF treatment | Photodynamic therapy (PDT) VISUDYNE® | |
---|---|---|---|
EYLEA® | LUCENTIS® | ||
A solution that is injected into the eye (intravitreal injection).
|
A solution that is injected into the eye (intravitreal injection).
|
A light-activated drug used in photodynamic therapy.
|
|
EYLEA® blocks VEGF-A and PIGF, proteins that play an important role in making the abnormal blood vessels that contribute to the progression of wAMD. EYLEA® has been shown to help improve vision or slow vision loss as well as the ability to perform related activities (e.g., reading, driving, etc.).
|
LUCENTIS® blocks VEGF-A, a protein that plays an important role in making the abnormal blood vessels that contribute to the progression of wAMD. LUCENTIS® has been shown to slow down the progression of vision loss and help improve vision as well as the ability to perform related activities (e.g., reading, driving, etc.).
|
VISUDYNE® is injected into a vein, usually in the arm, and travels to the abnormal blood vessels in the eye. After a few minutes, the doctor shines a non-thermal laser on the affected area of the eye to activate VISUDYNE®. This starts a chemical process that destroys the abnormal vessels growing in the macula and has been shown to slow vision loss from wAMD, slow or stop the growth of the areas containing the abnormal blood vessels and reduce or stop their leakage.
|
|
How often is it given?
Toggle show/hide. Screen reader users, all text is available without show hide.
|
Approximately 7 treatments in the first year: Once a month for the first three months then once every two months for the first twelve months of treatment.
4-6 treatments a year after the first year: EYLEA® may be administered up to once every three months based on your doctor's assessment.
|
6-12 treatments in the first year: Once a month for the first three months. Afterwards, your doctor will continue to monitor your vision and the frequency of dosing can be between one and three months:
4-12 treatments a year after the first year. LUCENTIS® given every 3 months was not as effective as when given once a month in clinical trials.
|
Approximately 4 treatments per year: Your doctor will reassess your symptoms every 3 months to determine if therapy should be repeated. The average number of treatments needed declines over time.
|
How is it administered?
Toggle show/hide. Screen reader users, all text is available without show hide.
|
The eye is disinfected and numbed and then the drug is injected into the eye.
|
The eye is disinfected and numbed and then the drug is injected into the eye.
|
The drug is injected into the bloodstream and a non-thermal laser applied to the affected area of the eye.
|
What are some possible common side effects?
Toggle show/hide. Screen reader users, all text is available without show hide.
|
Very common side effects:Bloodshot eye.
Common side effects: Decreased sharpness of vision, clouding of the lens, damage to the front layer of the eye, increase in eye pressure, blurred vision, moving spots in vision, detachment of the gel like substance inside the eye (vitreous) from the retina, a feeling of having something in the eye, increased tear production, swelling of the eyelid, eye pain, pain or bleeding at the injection site, redness of the eye and swelling of the front layer of the eyeball.
|
Very common side effects in the eye:Bloodshot eye, eye pain, small particles or spots in your vision, increased pressure inside the eye, displacement of the jelly-like portion inside the eye (vitreous body), swelling of the eye, blurred vision, eye irritation, clouding of the lens, a feeling of having something in the eye, visual disturbance, swelling or infection of the eyelid margin, formation of fibrous tissue under the retina, redness of the eye, blurred or decreased sharpness of vision, dry eye, inflammation of the jelly-like portion inside the eye, temporary blindness, increased tear production, itching of the eye, detachment of a layer of the retina.
Common side effects in the eye:Discomfort of the eye, clouding of a part of the lens, deposits in the back of the eye, infection of the surface of the eye, changes in the part of the retina responsible for central vision, bleeding in the back of the eye, degeneration of the retina, small scratches on the cornea (front part of the eye), bleeding in the eye or at the site of injection, tear or detachment of the retina, redness of the eye, light sensitivity, swelling of the eyelid, eyelid pain, eye discharge and bleeding in the jelly-like portion inside the eye.
|
Common side effectsChanges in vision including blurring, decreased sharpness, flashes of light and gaps or 'spider webs' in vision were among the most frequent+ly reported side effects. Temporary musculoskeletal pain occurring often as chest and back pain which can radiate to other areas including the pelvis, shoulder girdle or ribs. Weakness, nausea, constipation, hypertension, elevated blood cholesterol or urinary glucose, dry, itchy or painful eyes, aversion to light, decrease in pain or touch sensitivity, sunburn or increased sensitivity to the sun and injection site reactions (e.g., pain, swelling, blisters and discolouration).
|